Double click the "skeinforge.bat" for Skeinforge, this can be used to slice your models into GCode.
Double click the "Printrun.bat" for "PrintRun" this is a graphical command&control interface for your printer. This can run the generated GCode.
Linux/MacOSX: (experimental, no packaged python)
First you'll need to have python installed on your system! With pyserial when you want to use PrintRun. You do not need pypy, this is packaged with SkeinPyPy
Then run SkeinPyPy/skeinforge_application/skeinforge.py for skeinforge to slice your model
Or run printrun\\pronterface.py for the PrintRun interface to print your model